COMMON CARDIOVASCULAR DISEASE MODELS AND MODELING SCHEMES HYPERTENSION MODELS

1. Genetic Models of Hypertension Genetic hypertension models can simulate the genetic phenomena in humans, among which the spontaneously hypertensive rat (SHR) is the most commonly used. The blood pressure level in adult SHR rats is generally > 200 mmHg (1 mmHg = 0.133 kPa). There is no clear evidence of pathological disorder in the ear